Dr James Yun's publications

2022

Kim MY, Yun J, Kang DY, Kim TH, Oh MK, Lee S, et al. HLA-A*24:02 increase the risk of allopurinol-induced drug reaction with eosinophilia and systemic symptoms in HLA-B*58:01 carriers in a Korean population; a multicenter cross-sectional case-control study. Clin Transl Allergy. 2022 Sep 15;12(9):e12193.

James F, Goh MSY, Mouhtouris E, Vogrin S, Chua KYL, Holmes NE, Awad A, Copaescu AM, De Luca JF,

Zubrinich C, Gin D, Cleland H, Douglas A, Kern JS, Katelaris CH, Thien F, Barnes S, Yun J, et al. Study protocol: Australasian Registry of Severe Cutaneous Adverse Reactions (AUS-SCAR). BMJ Open. 2022 Aug 17;12(8):e055906.

Lee KH, Kang DY, Kim HH, Kim YJ, Kim HJ, Kim JH, Song EY, Yun J, Kang HR. Reducing severe cutaneous adverse and type B adverse drug reactions using pre-stored human leukocyte antigen genotypes. Clin Transl Allergy. 2022 Jan 14;12(1):e12098.

2021

Oh JH, Yun J, Yang MS, Kim JH, Kim SH, Kim S, et al. Reintroduction of Antituberculous Drugs in Patients with Antituberculous Drug-Related Drug Reaction with Eosinophilia and Systemic Symptoms. J Allergy Clin Immunol Pract. 2021 Apr 16:S2213-2198(21)00441-4.

Baird-Gunning J, Yun J, Stevenson W, Ng K. Severe Delayed-Onset Neutropenia Induced by Ocrelizumab. Neurohospitalist. 2021 Jan;11(1):59-61.

Jeong M, Kolovos P, Taper J, Yun J. The role of intravenous immunoglobulin in treatment of refractory Felty syndrome. Intern Med J. 2021 Feb;51(2):303-304.

Kang DY, Yun J, Lee SY, Koh YI, Sim DW, Kim S, et al. Korean Severe Cutaneous Adverse Reactions Consortium. A Nationwide Study of Severe Cutaneous Adverse Reactions Based on the Multicenter Registry in Korea. J Allergy Clin Immunol Pract. 2021 Feb;9(2):929-936.e7.

Yuheng Jiang J, Wong VCK, Yun J, Pathan F, Mansberg R. Disseminated sarcoidosis involving lymph nodes, bone and spleen with progressive cardiac sarcoidosis on 18F-FDG PET/CT and cardiac MRI. Radiol Case Rep. 2021 Sep 20;16(11):3610-3613

2020

Tang MM, Fok JS, Thong BY, Yun J, Li PH, Kang HR, et al. Diagnostic procedures & practices in drug allergy/hypersensitivity: a survey of 13 Asian countries. Asia Pac Allergy. 2020 Oct 15;10(4):e36

Kumari S, Yun J, Soares JR, Ding PN. Severe infusion reaction due to nivolumab: A case report. Cancer Rep (Hoboken). 2020 Jun;3(3):e1246.

Hambly TW, Wong NL, Yun J. Behçet disease-associated rhabdomyolysis treated with infliximab. Intern Med J. 2020 May;50(5):642-643.

Trubiano JA, Vogrin S, Chua KYL, Bourke J, Yun J, Douglas A, et al. Development and Validation of a Penicillin Allergy Clinical Decision Rule. JAMA Intern Med. 2020 Mar 16 (in press)

Chung SJ, Kang DY, Lee W, Lee SB, Kim S, Lee SE, Sim DW, Kang MG, Park KH, Jung JW, Yun J, Kang HR. HLA-DRB1*15: 02 Is Associated With Iodinated Contrast Media-Related Anaphylaxis. Invest Radiol. 2020 May;55(5):304-309.

Lee JH, Moon M, Kim YC, Chung SJ, Oh J, Kang DY, Lee SY, Lee KH, Yun J, Kang HR. A One-Bag Rapid Desensitization Protocol for Paclitaxel Hypersensitivity: A Non-inferior Alternative to a Multi-Bag Rapid Desensitization Protocol. J Allergy Clin Immunol Pract. 2020 Feb;8(2):696-703

Stevenson B, Trevenen M, Klinken E, Smith W, Yuson C, Katelaris C, Perram F, Burton P, Yun J, et al. Multicenter Australian Study to Determine Criteria for Low- and High-Risk Penicillin Testing in Outpatients. J Allergy Clin Immunol Pract. 2020 Feb;8(2):681-689.e3.

Thong BY, Lucas M, Kang HR, Chang YS, Li PH, Tang MM, Yun J, et al. Drug hypersensitivity reactions in Asia: regional issues and challenges. Asia Pac Allergy. 2020 Jan 30;10(1):e8.

2019

Park HJ, Yun J, Kang DY, Park JW, Koh YI, Kim S, Kim SH, Nam YH, Jeong YY, Kim CW, Park HK, Kim SH, Kang HR and Jung JW. Unique Clinical Characteristics and Prognosis of Allopurinol-Induced Severe Cutaneous Adverse Reactions J Allergy Clin Immunol Pract. 2019 Nov - Dec;7(8):2739-2749.e3.

Kim S, Yun J, Kang DY, Park HJ, Jo EJ, Jung JW, Park HK, Park JW, Jee YK, Kang HR and Lee JM. Carbonic anhydrase inhibitor-induced Stevens-Johnson syndrome/toxic epidermal necrolysis leads to extensive cutaneous involvement. J Allergy Clin Immunol Pract. 2019 2019 Nov - Dec;7(8):2851-2853.e2.

Shim JS, Yun J, Kim MY, Chung SJ, Oh JH, Kang DY, Jung JW, Cho SH and Kang HR. The Presence of HLA-B75, DR13 Homozygosity, or DR14 Additionally Increases the Risk of Allopurinol-Induced Severe Cutaneous Adverse Reactions in HLA-B*58:01 Carriers. J Allergy Clin Immunol Pract. 2019;7(4):1261-1270.

McDowall LM, Fernando SL, Ange N, Yun J, Chia KKM. Immune checkpoint inhibitor-mediated myocarditis and ventricular tachycardia storm. HeartRhythm Case Rep. 2019 Jun 28;5(10):497-500.

2018

Ange N, Alley S, Fernando SL, Coyle L and Yun J. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome successfully treated with mepolizumab. J Allergy Clin Immunol Pract. 2018;6(3):1059-1060

Cai F, Lucas M and Yun J. Dapsone-induced DRESS associated with HLA-B*13:01: an Australian experience. Internal Med J 2018;48(3):363-364

Rose M, Anderson J, Green S, Yun J and Fernando SL. Morphine and pholcodine specific IgE have limited utility in the diagnosis of anaphylaxis to benzylisoquinolines. Acta Anaesthesiol Scand 2018;62(5):628-634

2017

Massey J, Kumar K, Ng K, Yun J and Fernando SL. Skeletal myositis in relapsing drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. Annals of Allergy, Asthma & Immunology 2017;118(6):726-728.

Pichler W, Srinoulprasert Y, Yun J and Hausmann O. Multiple drug hypersensitivity. Int Arch Allergy Immunol. 2017;172(3):129-138

Ange N, McDowall LM, Yun J, Chia KKM and Fernando SL. Antithymocyte globulin for the treatment of checkpoint inhibitor mediated myocarditis. (abstract) Intern Med J 2017;47 (Suppl. 5):32

2016

Yun J, Cai F, Lee FJ, Pichler WJ. T-cell-mediated drug hypersensitivity: immune mechanisms and their clinical relevance. Asia Pac Allergy. 2016;6:77-89

Stamp LK, Day RO and Yun J. Allopurinol hypersensitivity: investigating the cause and minimizing the risk. Nat Rev Rheumatol. 2016;12:235-42

Yun J, Cai F and Fernando SL. One anaphylaxis caused by two structurally unrelated antibiotics with evidence of allergies to both compounds. (abstract) Intern Med J 2016;46 (Suppl. 4):13

Yun J, Cai F, Massey J, Brewer J, Kumar K and Fernando SL. Sulphasalazine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) associated with necrotising eosinophilic myositis – a novel finding. (abstract) Intern Med J 2016;46 (Suppl. 4):28

Anderson J, Fernando SL, Green S, Fulton RB, Yun J and Rose M. Morphine and pholcodine specific IgE testing has limited utility in the diagnosis of hypersensitivity to benzylisoquinoline neuromuscular blocking agents. (abstract) Intern Med J 2016;46 (Suppl. 4):12

2015

Pichler WJ, Adam J, Watkins S, Wuillemin N, Yun J and Yerly D. Drug Hypersensitivity: How Drugs Stimulate T Cells via Pharmacological Interaction with Immune Receptors. Int Arch Allergy Immunol. 2015;168:13-24.

2014

Yun J, Marcaida MJ, Eriksson KK, Jamin H, Fontana S, Pichler WJ and Yerly D. Oxypurinol directly and immediately activates the drug-specific T cells via the preferential use of HLA-B*58:01. J Immunol 2014;192:2984-93

Meyer N and Yun J. Allergies. In: Lammert E, Zeeb M, eds. Principles of Metabolism in Health and Disease. Wien: Springer, 2014:323-328

Yun J, Wienholt L and Adelstein S. Poor positive predictive value of serum IgG4 concentrations in the diagnosis of IgG4-related sclerosing disease. Asia Pac Allergy 2014;4:172-6

Yun J, Moussa M, Burton P, Perram F, Garsia R, Adelstein S and Katelaris C. Patients with positive beta-lactam skin tests had anaphylaxis, hospital presentations and/or reactions to parenteral beta-lactams. (abstract) Intern Med J 2014;44 (Suppl. 4):P95

Yun J, Wienholt L and Loblay R. Food-dependent exercise-induced anaphylaxis (FDEIA) due to Gly m 6 in soy. (abstract) Intern Med J 2014;44 (Suppl. 4):P94

2013

Yun J, Mattsson J, Schnyder K, Fontana S, Largiader C, Pichler W and Yerly D. Allopurinol hypersensitivity is mediated by dose dependent oxypurinol-specific T cell response. Clin Exp Allergy 2013;43:1246-55

2012

Yun J, Adam J, Yerly D and Pichler W. Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA. Allergy 2012;67:1338-46

2011

Yun J, Katelaris CH, Weerasinghe A, Adikari DB and Ratnayake C. Impact of chronic urticaria on the quality of life in Australian and Sri Lankan populations. Asia Pac Allergy 2011; 1:25-29.

2010

Yun J. Review of Handbook of Drug Metabolism, Second Edition. WAO News and Notes Email 2010:7(6)

2009

Yun J and Katelaris C. Food allergy in adolescents and adults, Intern Med J 2009;39:475-478

Yun J, Preda V and Frankum B. Chronic HHV 8 infection successfully treated with valganciclovir, World Allergy Organization Journal 2009;2:128-129

Yun J. Review of Trends in Innate Immunity. WAO News and Notes Email 2009;2(4)

2008

Yun JJ and Cheong I. Mannitol-induced hyperosmolal hyponatraemia, Intern Med J 2008; 38:73

Yun J. Book Review of Immunology, Infection, and Immunity. WAO News and Notes Email 2008; 5(12)

DR JAMES YUN'S PRESENTATIONS:

2021

Yun J. Early biomarkers for drug hypersensitivity. The Korean Academy of Asthma, Allergy

and Clinical Immunology; 2021 May 8, webinar.

2020

Yun J. Recent Advances in SCAR Research: Immunologic Aspects. International Online Symposium on the Status and Management of Adverse Drug Reactions in Korea; 2020 Sep 4, online symposium.

2018

Yun J. Management of antibiotic-induced SCAR. Oral presentation at: Antibiotic Allergy in Practice Workshop; 2019 Nov 3; Melbourne, Australia

Yun J. How to recognise and test delayed type hypersensitivity. Oral presentation at: 2018 ANZAAG Annual Symposium; 2018 Sep 14-15; Sunshine Coast, Australia

Yun J. The neglectd role of drug-dose in modifying immune mediated drug reactions. Oral presentation at: Drug Hypersensitivity Meeting 2018, 2018 April 19-21; Amsterdam, The Netherlands

Ange N and Yun J. Dual mechanisms for beta lactam allergy in a single patient. Poster presentation at: Drug Hypersensitivity Meeting 2018, 2018 April 19-21; Amsterdam, The Netherlands

Ange N, Tong W, Emerson J, Yusson C, n J, Hissaria, P and Yun J. First case series of patients treated with mepolizumab for drug reaction with eosinophilia and systemic symptoms (DRESS). Poster presentation at: Drug Hypersensitivity Meeting 2018, 2018 April 19-21; Amsterdam, The Netherlands

Yun J. Immune mechanisms in SCAR. Oral presentation at: Macarthur Series in Immunology; 2018 Mar 11; Sydney, Australia

Yun J. and Ange N. DRESS and use of mepolizumab. Oral presentation at: Macarthur Series in Immunology; 2018 Mar 11; Sydney, Australia

2017

Ange N, McDowall L, Yun J, Chia KKM, Fernando S. Antithymocyte globulin for the treatment of checkpoint hibitor mediated myocarditis, Oral presentation at: ASCIA Annual Scientific Meeting; 2017 Sep 13-15; Auckland, New Zealand

2016

Yun J. Angioedema. Oral presentation at: 2016 ANZAAG Annual Symposium; 2016 August 12-14; Melbourne, Australia

Yun J. The role of immune receptors in HLA associated drug hypersensitivity - Allopurinol and HLA-B*58:01 story. Oral presentation at: Immunoproteomics Laboratory at Monash University 2016 August 12; Australia

Yun J. Severe adverse drug reactions and HLA associations. Oral presentation at: Macarthur Series in Immunology; 2016 Mar 19; Sydney, Australia

2015

Yun J. HLA associated drug hypersensitivity - the allopurinol story. Oral presentation at: RCPA Pathology Update; 2015 Feb 28; Melbourne, Australia

Yun J. The role of immune receptors in HLA associated drug hypersensitivity. Oral presentation at: 2015 International Conference on Pharmacogenomics, 2015 Feb 24; Seoul, Korea

2014

Yun J. Allopurinol hypersensitivity: complex interaction between drug and immune receptors. Oral presentation at: Therapeutic Centre Research Seminar at St Vincent’s Hospital, 2014 Nov 28; Sydney, Australia

Yun J. Allopurinol hypersensitivity: drug, HLA and T cells. Oral presentation at: Rheumatology department meeting at Liverpool Hospital, 2014 Nov 13; Sydney, Australia

Yun J. Allopurinol hypersensitivity. Oral presentation at: Gout Special Interest Forum, 2014 Sep 12-13; Sydney, Australia

Yun J, Pichler W and Yerly D. Allopurinol Hypersensitivity: complex interplay between drug, TCR and pHLA. Oral presentation at: DHM6 2014 Drug Hypersensitivity Meeting, 2014 Apr 10; Bern, Switzerland

Yun J, Wienholt L and Loblay R. Food-dependent exercise-induced anaphylaxis (FDEIA) due to Gly m 6 in soy. Poster session presented at: ASCIA Annual Scientific Meeting; 2014 Sep 10-12; Melbourne, Australia

2013

Yun J, Pichler W and Yerly D. T cell reactivity to allopurinol and oxypurinol - deciphering allopurinol hypersensitivity. Oral presentation at: Joint Group Meeting, Immunology research groups, 2013 Jun 20; Bern, Switzerland

Yun J, Mattsson J, Schnyder K, Fontana S, Largiadèr C, Pichler W and Yerly D. Allopurinol hypersensitivity is primarily directed to oxypurinol and is dose dependent. Poster session presented at: Joint Annual Meeting SSAI and SGP; 2013 Apr 17-19; Bern, Switzerland

Yun J, Yerly D, Fontana S and Pichler W. Allopurinol hypersensitivity is caused by direct and immediate activation of Allopurinol/Oxypurinol-specific T cells by the drugs using TCR-MHC interaction. Poster session presented at: GCB Students’ Symposium 2013; 2013 Jan 30; Bern, Switzerland

2012

Yun J, Yerly D, Fontana S and Pichler W. The role of drug concentrations in the generation of Allopurinol/Oxypurinol-specific T cells in vitro. Poster session presented at: EAACI Congress; 2012 Jun 16-20; Geneva, Switzerland

Yun J, Yerly D, Fontana S and Pichler W. Generation of Allopurinol/Oxypurinol-specific T cells in vitro. Poster session presented at: DHM5 2012 Drug Hypersensitivity Meeting; 2012 Apr 11-14; Munich, Germany

Yun J, Yerly D and Pichler W. Deciphering Allopurinol Hypersensitivity – Characterisation of risk factors for allopurinol hypersensitivity in vitro. Poster session presented at: XXIX Meeting of the Swiss Immunology PhD Students; 2012 Apr 2-4; Wolfsberg, Switzerland

2010

Yun J, Limaye S and Papathomas E. Correlation of serum protein electrophoresis with nephelometry in the diagnosis of hypogammaglobulinaemia. Poster session presented at: RCPA Pathology Update; 2010 Feb 26-28; Melbourne, Australia

Moussa M, Yun J and Adelstein S. Positive skin tests to a radiographic contrast media following an allergic reaction after angiography. Poster session presented at: ASCIA Annual Scientific Meeting; 2010 Sep 1-3; Gold Coast, Australia

2009

Yun J and Katelaris C. Characterisation of type B adverse drug reactions in medical inpatients at a teaching hospital in Sydney. Poster session presented at: XXI World Allergy Congress; 2009 Dec 6-10; Buenos Aires, Argentina

2008

Yun J, Katelaris C, Weerasinghe A, Adikari DB and Ratnayake C. Comparing the Impact of Chronic Urticaria on the Quality of Life in Australian and Sri Lankan Population. Poster session presented at: ASCIA Annual Scientific Meeting; 2008 Nov 12-14; Melbourne, Australia

Yun J and Frankum B. Chronic Human Herpes Virus 8 Infection Treated with Valganciclovir. Poster session presented at: ASCIA Annual Scientific Meeting; 2008 Nov 12-14; Melbourne, Australia